It all began on November 21, 1992, when His Holiness John Paul II, through the Papal Bull, an official Church document Quod iusta quidem, announced the creation of the new Catholic Diocese of Koforidua, the tenth in Ghana, carved from the then Diocese of Accra.

That same day, through another Bull Cum primus sit, the Holy Father appointed Rev. Fr. Gabriel Charles PALMER-BUCKLE first Bishop of the newly created diocese, and he was ordained by the Holy Father John Paul II on January 6, 1993, Feast of the Epiphany, in the St. Peter’s Basilica, Rome in Italy.

One month later on February 6, 1993 Bishop Palmer-Buckle was solemnly enthroned in the St. George’s Catholic Cathedral at Koforidua. He was subsequently transferred to Accra Archdiocese when the seat became vacant in May, 2005.

Between May 2005-April 2006, Msgr. Joseph Afrifah-Agyekum became the Administrator of the diocese. On the 12th of April, 2006 he was appointed the second bishop of the diocese by Pope Benedict XVI. His consecration took place on the 1st of July, 2006.

The Diocese, 18,600 Sq. Kms, covers almost the entire Eastern Region of Ghana. The eastern border lies on the Volta Lake. This lake was formed in the 1960s by damming the Volta River and is one of the largest man-made lakes in the world.

Koforidua is the municipal capital of the region, with about 136,768 inhabitants.

The Regional Population is about 2, 387,500 of which about 41.7% are below 15 years. 65.4% of the population live in rural areas. Most inhabitants are subsistence farmers and a few fishermen. The remainder live in urban areas where they support themselves through petty trading, casual labour and salaried jobs. The native inhabitants are Akim, Kwahu, Juaben, Akwapim, Guan, Krobo and Akwamu. There are settlers from all over the country and even outside Ghana.
According to the 2000 census, about 201,335 are Catholics; nearly 10% of the Regional Population and are spread throughout the Region. The rest of the population is made up of other Christian denominations (namely Protestants and Pentecostals), Moslems and followers of various traditional beliefs.